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Hybrid quantum–HPC computing with trapped ions is here

March 2, 2026

Japan has made bold, strategic investments in both high-performance computing (HPC) and quantum technologies. As these capabilities mature, an important question arises for policymakers and research leaders: how do we move from building advanced machines to demonstrating meaningful, integrated use?

Last year, ĢƵ installed its Reimei quantum computer at a world-class facility in Japan operated by RIKEN, the country’s largest comprehensive research institution. The system was integrated with Japan’s famed supercomputer Fugaku, one of the most powerful in the world, as part of an ambitious national project commissioned by the New Energy and Industrial Technology Development Organization (NEDO), the national research and development entity under the Ministry of Economy, Trade and Industry.

Now, for the first time, a full scientific workflow has been executed across Fugaku, one of the world’s most powerful supercomputers, and Reimei, our trapped-ion quantum computer. This marks a transition from infrastructure development to practical deployment.

Quantum Biology

In this first foray into hybrid HPC-quantum computation, the team explored chemical reactions that occur inside biomolecules such as proteins. Reactions of this type are found throughout biology, from enzyme functions to drug interactions.

Simulating such reactions accurately is extremely challenging. The region where the chemical reaction occurs—the “active site”—requires very high precision, because subtle electronic effects determine the outcome. At the same time, this active site is embedded within a much larger molecular environment that must also be represented, though typically at a lower level of detail.

To address this complexity, computational chemistry has long relied on layered approaches, in which different parts of a system are treated with different methods. In our work, we extended this concept into the hybrid computing era by combining classical supercomputing with quantum computing.

Shifting the Paradigm

While the long-term goal of quantum computing is to outperform classical approaches alone, the purpose of this project was to demonstrate a fully functional hybrid system working as an end-to-end platform for real scientific applications. We believe it is not enough to develop hardware in isolation – we must also build workflows where classical and quantum resources create a whole that is greater than the parts. We believe this is a crucial step for our industry; large-scale national investments in quantum computing must ultimately show how the technology can be embedded within existing research infrastructure.

In this work, the supercomputer Fugaku handled geometry optimization and baseline electronic structure calculations. The quantum computer Reimei was used to enhance the treatment of the most difficult electronic interactions in the active site, those that are known to challenge conventional approximate methods. The entire process was coordinated through ĢƵ’s workflow system , which allows jobs to move efficiently between machines.

Hybrid Computation is Now an Operational Reality

With this infrastructure in place, we are now poised to truly leverage the power of quantum computing. In this instance, the researchers designed the algorithm to specifically exploit the strengths of both the quantum and the classical hardware.

First, the classical computer constructs an approximate description of the molecular system. Then, the quantum computer is used to model the detailed quantum mechanics that the classical computer can’t handle. Together, this improves accuracy, extending the utility of the classical system.

A Path to Hybrid Advantage

Accurate simulation of biomolecular reactions remains one of the major challenges in biochemistry. Although the present study uses simplified systems to focus on methodology, it lays the groundwork for future applications in drug design, enzyme engineering, and photoactive biological systems.

While fully fault-tolerant, large-scale quantum computers are still under development, hybrid approaches allow today’s quantum hardware to augment powerful classical systems, such as Fugaku, to explore meaningful applications. As quantum technology matures, the same workflows can scale accordingly.

High-performance computing centers worldwide are actively exploring how quantum devices might integrate into their ecosystems. By demonstrating coordinated job scheduling, direct hardware access, and workflow orchestration across heterogeneous architectures, this work offers a concrete example of how such integration can be achieved.

As quantum hardware matures, we believe the algorithms and workflows developed here can be extended to increasingly realistic and industrially relevant problems. For Japan’s research ecosystem, this first application milestone signals that hybrid quantum–supercomputing is moving from ambition to implementation.

About ĢƵ

ĢƵ, the world’s largest integrated quantum company, pioneers powerful quantum computers and advanced software solutions. ĢƵ’s technology drives breakthroughs in materials discovery, cybersecurity, and next-gen quantum AI. With over 500 employees, including 370+ scientists and engineers, ĢƵ leads the quantum computing revolution across continents. 

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March 25, 2026
Celebrating Our First Annual Q-Net Connect!

This month, ĢƵ welcomed its global user community to the first-ever Q-Net Connect, an annual forum designed to spark collaboration, share insights, and accelerate innovation across our full-stack quantum computing platforms. Over two days, users came together not only to learn from one another, but to build the relationships and momentum that we believe will help define the next chapter of quantum computing.

Q-Net Connect 2026 drew over 170 attendees from around the world to Denver, Colorado, including representatives from commercial enterprises and startups, academia and research institutions, and the public sector and non-profits - all users of ĢƵ systems.  

The program was packed with inspiring keynotes, technical tracks, and customer presentations. Attendees heard from leaders at ĢƵ, as well as our partners at NVIDIA, JPMorganChase and BlueQubit; professors from the University of New Mexico, the University of Nottingham and Harvard University; national labs, including NIST, Oak Ridge National Laboratory, Sandia National Laboratories and Los Alamos National Laboratory; and other distinguished guests from across the global quantum ecosystem.

Congratulations to Q-Net Connect 2026 Award Recipients! 

The mission of the ĢƵ Q-Net user community is to create a space for shared learning, collaboration and connection for those who adopt ĢƵ’s hardware, software and middleware platform. At this year’s Q-Net Connect, we awarded four organizations who made notable efforts to champion this effort. 

  • JPMorganChase received the ‘Guppy Adopter Award’ for their exemplary adoption of our quantum programming language, Guppy, in their research workflows. 
  • Phasecraft, a UK and US-based quantum algorithms startup, received the ‘Rising Star’ award for demonstrating exceptional early impact and advancing science using ĢƵ hardware, which they published in a December 2025 .
  • Qedma, a quantum software startup, received the ‘Startup Partner Engagement’ award for their sustained engagement with ĢƵ platforms dating back to our first commercially deployed quantum computer, H1.
  • Anna Dalmasso from the University of Nottingham received our ‘New Student Award’ for her impressive debut project on ĢƵ hardware and for delivering outstanding results as a new Q-Net student user. 

Congratulations, again, and thank you to everyone who contributed to the success of the first Q-Net Connect!

Become a Q-Net Member

Q-Net offers year‑round support through user access, developer tools, documentation, trainings, webinars, and events. Members enjoy many exclusive benefits, including being the first to hear about exclusive content, publications and promotional offers.

By joining the community, you will be invited to exclusive gatherings to hear about the latest breakthroughs and connect with industry experts driving quantum innovation. Members also get access to Q‑Net Connect recordings and stay connected for future community updates.

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March 16, 2026
We’re Using AI to Discover New Quantum Algorithms

In a follow-up to our recent work with Hiverge using AI to discover algorithms for quantum chemistry, we’ve teamed up with Hiverge, Amazon Web Services (AWS) and NVIDIA to explore using AI to improve algorithms for combinatorial optimization.

With the rapid rise of Large Language Models (LLMs), people started asking “what if AI agents can serve as on-demand algorithm factories?” We have been working with Hiverge, an algorithm discovery company, AWS, and NVIDIA, to explore how LLMs can accelerate quantum computing research.

Hiverge – named for Hive, an AI that can develop algorithms – aims to make quantum algorithm design more accessible to researchers by translating high-level problem descriptions in mostly natural language into executable quantum circuits. The Hive takes the researcher’s initial sketch of an algorithm, as well as special constraints the researcher enumerates, and evolves it to a new algorithm that better meets the researcher’s needs. The output is expressed in terms of a familiar programming language, like Guppy or , making it particularly easy to implement.

The AI is called a “Hive” because it is a collective of LLM agents, all of whom are editing the same codebase. In this work, the Hive was made up of LLM powerhouses such as Gemini, ChatGPT, Claude, Llama, as well as which was accessed through AWS’ Amazon Bedrock service. Many models are included because researchers know that diversity is a strength – just like a team of human researchers working in a group, a variety of perspectives often leads to the strongest result.

Once the LLMs are assembled, the Hive calls on them to do the work writing the desired algorithm; no new training is required. The algorithms are then executed and their ‘fitness’ (how well they solve the problem) is measured. Unfit programs do not survive, while the fittest ones evolve to the next generation. This process repeats, much like the evolutionary process of nature itself.

After evolution, the fittest algorithm is selected by the researchers and tested on other instances of the problem. This is a crucial step as the researchers want to understand how well it can generalize.

In this most recent work, the joint team explored how AI can assist in the discovery of heuristic quantum optimization algorithms, a class of algorithms aimed at improving efficiency across critical workstreams. These span challenges like optimal power grid dispatch and storage placement, arranging fuel inside nuclear reactors, and molecular design and reaction pathway optimization in drug, material, and chemical discovery—where solutions could translate into maximizing operational efficiency, dramatic reduction in costs, and rapid acceleration in innovation.

In other AI approaches, such as reinforcement learning, models are trained to solve a problem, but the resulting "algorithm" is effectively ‘hidden’ within a neural network. Here, the algorithm is written in Guppy or CUDA-Q (or Python), making it human-interpretable and easier to deploy on new problem instances.

This work leveraged the NVIDIA CUDA-Q platform, running on powerful NVIDIA GPUs made accessible by AWS. It’s state-of-the art accelerated computing was crucial; the research explored highly complex problems, challenges that lie at the edge of classical computing capacity. Before running anything on ĢƵ’s quantum computer, the researchers first used NVIDIA accelerated computing to simulate the quantum algorithms and assess their fitness. Once a promising algorithm is discovered, it could then be deployed on quantum hardware, creating an exciting new approach for scaling quantum algorithm design.

More broadly, this work points to one of many ways in which classical compute, AI, and quantum computing are most powerful in symbiosis. AI can be used to improve quantum, as demonstrated here, just as quantum can be used to extend AI. Looking ahead, we envision AI evolving programs that express a combination of algorithmic primitives, much like human mathematicians, such as Peter Shor and Lov Grover, have done. After all, both humans and AI can learn from each other.

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March 16, 2026
Real Time Error Correction at Increased Scale

As quantum computing power grows, so does the difficulty of error correction. Meeting that demand requires tight integration with high-performance classical computing, which is why we’ve partnered with NVIDIA to push the boundaries of real-time decoding performance.

Realizing the full power of quantum computing requires more than just qubits, it requires error rates low enough to run meaningful algorithms at scale. Physical qubits are sensitive to noise, which limits their capacity to handle calculations beyond a certain scale. To move beyond these limits, physical qubits must be combined into logical qubits, with errors continuously detected and corrected in real time before they can propagate and corrupt the calculation. This approach, known as fault tolerance, is a foundational requirement for any quantum computer intended to solve problems of real-world significance.

Part of the challenge of fault tolerance is the computational complexity of correcting errors in real time. Doing so involves sending the error syndrome data to a classical co-processor, solving a complex mathematical problem on that processor, then sending the resulting correction back to the quantum processor - all fast enough that it doesn’t slow down the quantum computation. For this reason, Quantum Error Correction (QEC) is currently one of the most demanding use-cases for tight coupling between classical and quantum computing.

Given the difficulty of the task, we have partnered with NVIDIA, leaders in accelerated computing. With the help of NVIDIA’s ultra-fast GPUs (and the GPU-accelerated BP-OSD decoder developed by NVIDIA as part of library), we were able to demonstrate real-time decoding of Helios’ qubits, all in a system that can be connected directly to our quantum processors using .

While real-time decoding has been demonstrated before (notably, by our own scientists in this study), previous demonstrations were limited in their scalability and complexity.

In this demonstration, we used Brings’ code, a high-rate code that is possible with our all-to-all connectivity, to encode our physical qubits into noise-resilient logical qubits. Once we had them encoded, we ran gates as well as let them idle to see if we could catch and correct errors quickly and efficiently. We submitted the circuits via both as well as our own Guppy language, underlining our commitment to accessible, ecosystem-friendly quantum computing.

The results were excellent: we were able to perform low-latency decoding that returned results in the time we needed, even for the faster clock cycles that we expect in future generation machines.

A key part of the achievement here is that we performed something called “correlated” decoding. In correlated decoding, you offload work that would normally be performed on the QPU onto the classical decoder. This is because, in ‘standard’ decoding, as you improve your error correction capabilities, it takes more and more time on the QPU. Correlated decoding elides this cost, saving QPU time for the tasks that only the quantum computer can do.

Stay tuned for our forthcoming paper with all the details.

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